Colorado, currently 3-3 on the season, must win three out of their six games to become Bowl eligible for the first time since 2007.
The Wildcat enters Saturday's match-up 4-2 overall and 1-2 in league play while the Buffs are currently 0-3 in league action and is in search of their first Pac 12 win.
"We realize how important Saturday's game is going to be," Coach Mike MacIntyre said earlier this week. "We don't really talk about being bowl eligible, it's something that hasn't been relevant here in sometime. We know that we are going to have to play better, to coach better and see if we can get six wins, first we have to take care of business this weekend."
The Wildcats are led by junior running back Ka'Deem Carey. Carey was the National rushing champion as a sophomore and is currently leading the NCAA with rushing with 160. 2 yards per game.
Carey led Arizona against Utah with 39 carries for 232 yards and a touchdown.
MacIntyre is very well aware of what type of threat Carey will provide for the Buffs defense.
"He is phenomenal player, I wished we were playing Jim Carey instead of Ka'Deem," MacIntyre said. "He is an unbelievable player, not only is he a great runner, he is a physical tough guy, really makes things happen for them."
MacIntyre also feels that Arizona has definitely shown improvement on defense in their second year in the Rich Rodriquez era for the Wildcats.
"They have definitely got better defensively," MacIntyre said. "From watching film from last year to this year, they have drastically improved. Second year in the same system, they are a really good football team and it should be a good game for us. We know we must play better in Pac 12 and thats what we plan on doing."
MacIntyre felt that his team turned in their best Tuesday practice, a positive sign that they players are turning it up a notch heading back into league play.
"I thought we practice really well today, I know I say that a lot, but it really was our best Tuesday practice of the year," MacIntyre said. "Maybe it was the sunlight, maybe the game win or the excitement of the upcoming league game, they had a little extra pep in their step. Hopefully it will show up on Saturday."
Arizona won last year's contest in Tucson 56-31, it was a game that Colorado were in for one half before 21 unanswered points in the third quarter. The Buffs trailed 28-17 at the intermission.
Colorado is coming off a 43-10 win going into Pac 12 play, instead of coming off a three week layoff when they began Pac 12 play at Oregon State.
"Our guys are excited about being back in Pac 12 action," MacIntyre said. "We know that we are going to have to play really well, we have six more games and it's very important we start that six game stretch and play a lot better in league play."
Game time for Saturday's matchup will be at 6:00 p.m. mountain time and will be televised on the PAC 12 Network.