It only took a minute and five seconds for the nation's top scoring team to put six on the board.
By the time the clock wound down in the fourth quarter, the Ducks scored more points against USC than any other Trojan opponent in the program's 124 year history, on their way to a 62-51 victory.
"Like we talked about last night, it felt like it would be like a heavy weight championship fight, and there would be huge blows dealt throughout the day," USC Coach Lane Kiffin said after the game.
Perhaps the biggest blow is the record now staring back at the preseason favorite to play for a national championship, as USC falls to 6-3 just a week into the final month of the season.
The Ducks jumped out to a 21-3 second quarter lead, led by redshirt senior running back Kenjon Barner. Barner amassed 321-yards on 38 carries and finished with five touchdowns, setting a new USC-opponent record for most rushing yards in a single game.
"Obviously they moved the ball," Kiffin said. "They had really good players who played great today."
The Trojans fumbled a chance to pull within a field goal heading into the half as sophomore receiver Marqise Lee lost the ball trying to make his way to the end zone.
"Unfortunately we shot ourselves in the foot," Kiffin said. "We kicked a field goal early. No points on the interception. And the fumble in the redzone, that makes a big difference."
Senior quarterback Matt Barkley threw two first half interceptions. He finished the 35-of-54 for 484 yards and five touchdowns.
Down by ten coming out of the break, Barkley handed off to senior tailback Silas Redd who rushed for one of his two touchdowns of the night to pull USC within three.
But the shootout continued and USC's defense was unable to come up with a stop, as the Ducks continued to feed Barner.
Neither team punted the ball until the fourth quarter, when the Trojans were deep in their own territory and facing fourth down. The punt effectively ended the shootout and put the game out of reach for USC.
The Duck's 730-yards broke the USC opponent record for total yards, a record standing since 1946 at 623 yards set by Notre Dame.
Asked after the game if he thought the Trojans could score 51 points and lose, Barkley said "Oregon's been doing this all year. We knew it would be a shootout like this but we did leave points on the board, which is what I'm thinking about."
Despite the costly fumble, Lee made 12 catches for 157 and two touchdowns, piling up 408-all purpose yards for the night.
The loss drops USC to 6-3 as Oregon remains undefeated, improving to 9-0.
USC is back in action next Saturday hosting Arizona State.
Kevin Carden contributed to this video.